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Methylglyoxal evokes pain by stimulating TRPA1
Factors that can lower the threshold for overdose or increase the likelihood of liver failure include: Delays in treatment
The more significant metabolic benefit tends to come indirectly: as body weight decreases, markers like blood pressure, cholesterol, and blood sugar often improve, which can positively influence long-term metabolic health
Patients who took a GLP-1 agonist were nearly 50% less likely to receive a colon cancer diagnosis
PMID: 36618536
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